Scabies infections are usually treated with a prescription lotion that kills the mites. The lotion must be applied to the entire body from the neck down. This includes the palms of the hands, soles of the feet, groin, and under the fingernails. The lotion must be left on for 8 to 14 hours or as prescribed. The lotion is often used at night before bed and then washed off the next morning. In some cases, the child or adult may need a second application of lotion a week after the first. Medicines work quickly to kill the mites, but most children and adults continue to have an itchy reaction to the bites they've already gotten for several weeks after treatment. Marks on the skin from scabies usually go away in 1 to 2 weeks, but sometimes they take a few months. If the skin creams don't work, the child or adult may need to take medicine by mouth (orally).