Researchers are doing studies to learn the causes of IEI. It's not an allergic reaction. It does not cause the release of chemicals by the immune system. A physical cause is hard to find. Because of this, some studies suggest IEI may be linked to psychiatric disorders. These include somatoform disorders, depression, and anxiety. IEI occurs more often in women than in men. IEI happens more often in people in their 30s or 40s.