The most common cause of hypothyroidism is an autoimmune disorder. This means your immune system sees your normal tissues as strange and starts to attack itself. It makes antibodies against the thyroid gland. The normal thyroid cells are overrun by white blood cells and scar tissue. Another cause may be treatment for an overactive thyroid gland. That may include radioactive iodine therapy or surgery. Hypothyroidism may also develop shortly after pregnancy.
A condition called secondary hypothyroidism can also sometimes happen. It's when your pituitary gland does not make enough thyroid stimulating hormone. The pituitary gland then no longer tells the thyroid gland to make enough thyroid hormones.
Newborns are tested at birth for hypothyroidism. This condition is called congenital hypothyroidism. It must be treated right away. It can affect a baby's brain and nervous system.