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Cone Biopsy

A cone biopsy is a quick outpatient surgery used to find and treat a problem in the cervix. Your healthcare provider may do a cone biopsy if one or more Pap tests and a colposcopy (microscope) exam showed abnormal cells on your cervix. A cone biopsy takes less than an hour. You’ll be able to go home the same day. The most common type of cone biopsy is the loop electrosurgical excision procedure (LEEP). A wire with electric current is used to take the biopsy.

Cross section of uterus with inset showing closeup of cervix.

Preparing for a cone biopsy

Follow any directions you are given for not eating or drinking before surgery. You’ll also need to have an adult friend or family member drive you home after the procedure. On the day of surgery, be sure to arrive at the hospital, surgery center, or healthcare provider's office in time to sign in and get ready for your procedure.

Your surgery

Here is what to expect during surgery:

  • You’ll be given anesthesia before your biopsy to keep you comfortable during surgery.

  • Your healthcare provider then puts a thin metal tool (speculum) into your vagina to spread it open. This allows your healthcare provider to see your cervix.

  • Then a cone-shaped piece of tissue is removed from the cervix. The tissue is cut from the opening up into the canal. This may be done with a small knife or with a laser or with the LEEP wire.

  • A special cream may be put on your cervix to control bleeding. 

  • The tissue that is removed is then sent to the lab. The lab studies the tissue and makes sure the abnormal cells have been cut away. New tissue grows back in the cervix in 4 to 6 weeks.

Recovery from a cone biopsy

After the procedure, you may have:

  • A pink, liquid discharge

  • Mild cramps

  • A dark-colored discharge (from the cream used)

Don’t use tampons, don’t douche, and don’t have sex until your healthcare provider says it's OK.

When to call your healthcare provider

Call your healthcare provider if you have:

  • Heavy bleeding, or bleeding with clots

  • Fever over 100.4°F (38°C) or higher, or as directed by your healthcare provider

  • Chills

  • Bad-smelling vaginal discharge

Possible risks of a cone biopsy

Your healthcare provider will discuss the risks and possible complications of cone biopsy with you. These include:

  • Not removing all of the abnormal tissue

  • Severe bleeding

  • Infection

  • Weakening or scarring of the cervix that could lead to preterm birth

Online Medical Reviewer: Donna Freeborn PhD CNM FNP
Online Medical Reviewer: Heather M Trevino BSN RNC
Online Medical Reviewer: Irina Burd MD PhD
Date Last Reviewed: 8/1/2022
© 2000-2024 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.